Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication

• Published in: Doklady. Biochemistry and biophysics Vol. 507; no. 1; pp. 357 - 362
• Main Authors: Paramonova, M. P., Gureeva, E. S., Ozerov, A. A., Snoeck, R., Andrei, G., Alexandrov, D. A., Handazinskaya, A. L., Novikov, M. S., Kochetkov, S. N.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-12-2022; Springer Nature B.V
• Subjects: Anthracene; Antiviral activity; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Biochemistry; Biochemistry, Biophysics, and Molecular Biology; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Cytomegalovirus; Humans; Life Sciences; Molecular Biology; Structure-Activity Relationship; Uracil; Uracil - chemistry; Uracil - pharmacology; synthesis; antiviral activity; human cytomegalovirus; uracil derivatives
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S1607672922340099

A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing naphthalen-1-yl, naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene-9-ylmethyl fragments in position 3 of uracil residue was synthesized. The antiviral properties of the synthesized compounds against human cytomegalovirus were studied. It was found that the compound containing a bridge consisting of five methylene groups exhibits a high anti-cytomegalovirus activity in vitro.