Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease

• Published in: Cognitive computation Vol. 10; no. 6; pp. 1006 - 1018
• Main Authors: Mekyska, Jiri, Galaz, Zoltan, Kiska, Tomas, Zvoncak, Vojtech, Mucha, Jan, Smekal, Zdenek, Eliasova, Ilona, Kostalova, Milena, Mrackova, Martina, Fiedorova, Dagmar, Faundez-Zanuy, Marcos, Solé-Casals, Jordi, Gomez-Vilda, Pedro, Rektorova, Irena
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-12-2018; Springer Nature B.V
• Subjects: Acoustic measurement; Acoustics; Artificial Intelligence; Biomedical and Life Sciences; Biomedicine; Cognitive ability; Computation by Abstract Devices; Computational Biology/Bioinformatics; Correlation analysis; Disease; Disorders; Dysarthria; Gait; Intelligibility; Linguistics; Neurosciences; Parkinson's disease; Phonation; Quality of life; Quantitative analysis; Questionnaires; Regression models; Signs and symptoms; Speech; Velocity; Walking; Freezing of gait; Parkinson’s disease; Acoustic analysis; Hypokinetic dysarthria; Quantitative analysis
• ISSN: 1866-9956; 1866-9964
• DOI: 10.1007/s12559-018-9575-8

Hypokinetic dysarthria (HD) and freezing of gait (FOG) are both axial symptoms that occur in patients with Parkinson’s disease (PD). It is assumed they have some common pathophysiological mechanisms and therefore that speech disorders in PD can predict FOG deficits within the horizon of some years. The aim of this study is to employ a complex quantitative analysis of the phonation, articulation and prosody in PD patients in order to identify the relationship between HD and FOG, and establish a mathematical model that would predict FOG deficits using acoustic analysis at baseline. We enrolled 75 PD patients who were assessed by 6 clinical scales including the Freezing of Gait Questionnaire (FOG–Q). We subsequently extracted 19 acoustic measures quantifying speech disorders in the fields of phonation, articulation and prosody. To identify the relationship between HD and FOG, we performed a partial correlation analysis. Finally, based on the selected acoustic measures, we trained regression models to predict the change in FOG during a 2-year follow-up. We identified significant correlations between FOG–Q scores and the acoustic measures based on formant frequencies (quantifying the movement of the tongue and jaw) and speech rate. Using the regression models, we were able to predict a change in particular FOG–Q scores with an error of between 7.4 and 17.0 %. This study is suggesting that FOG in patients with PD is mainly linked to improper articulation, a disturbed speech rate and to intelligibility. We have also proved that the acoustic analysis of HD at the baseline can be used as a predictor of the FOG deficit during 2 years of follow-up. This knowledge enables researchers to introduce new cognitive systems that predict gait difficulties in PD patients.