Expression of Galectins-1 and Galectin-3 in Stomach and Colorectal Cancer with Tissue Eosinophilia

• Published in: Bulletin of experimental biology and medicine Vol. 165; no. 2; pp. 256 - 258
• Main Authors: Kolobovnikova, Yu. V., Dmitrieva, A. I., Yankovich, K. I., Vasil’eva, O. A., Purlik, I. L., Poletika, V. S., Novitskii, V. V., Urazova, O. I.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-06-2018; Springer; Springer Nature B.V
• Subjects: Aged; Biomedical and Life Sciences; Biomedicine; Blood diseases; Cell Biology; Chemotaxis, Leukocyte - physiology; Cohort Studies; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - complications; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Eosinophilia; Eosinophilia - complications; Eosinophilia - metabolism; Eosinophilia - pathology; Eosinophils - metabolism; Eosinophils - pathology; Galectin 1 - metabolism; Galectin 3 - metabolism; Galectin-1; Galectin-3; Gastric Mucosa - metabolism; Gastrointestinal diseases; Gastrointestinal system; Humans; Internal Medicine; Laboratory Medicine; Leukocytes (eosinophilic); Medical research; Metastases; Middle Aged; Oncology; Pathology; Protein binding; Stomach; Stomach - pathology; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Tumors; eosinophilia; cancer; gastrointestinal tract; galectins
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-018-4142-6

We analyzed the expression of galectin-1 and galectin-3 in tumor tissue in stomach and colorectal cancer with and without tissue eosinophilia. Low expression of galectin-3 was detected in all patients with malignant gastrointestinal tumors irrespective of the presence of eosinophilia. Low expression of galectin-1 was detected only in patients with gastrointestinal cancer associated with eosinophilia. Association of galectin-1 expression with eosinophilic infiltration of the tumor tissue in stomach and colorectal cancer was detected.