Clinical implication of children's depression rating scale-revised score: Linking the children's depression rating scale-revised score and clinical global impression using patients data from clinical trials

• Published in: Health science reports Vol. 6; no. 9; pp. e1512 - n/a
• Main Authors: Yoshimatsu, Hiroki, Imaeda, Takayuki, Higa, Shingo, Nomoto, Keisuke
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-09-2023; John Wiley and Sons Inc; Wiley
• Subjects: antidepressants; Cardiology; Children & youth; clinical global impression; Clinical trials; Epidemiology; Gastroenterology/Hepatology; General Medicine; Genetics and Genomics; Global Health; Health Policy; linking analysis; major depression; Medical Education; Mental depression; Neurology; Nutrition, Obesity and Exercise; Original Research; Pharmacology and Pharmacy; Psychiatry; Public Health; Radiology & Imaging; Teenagers; United States > US; clinical global impression; linking analysis; antidepressants; major depression
• ISSN: 2398-8835; 2398-8835
• DOI: 10.1002/hsr2.1512

The Children's Depression Rating Scale-Revised (CDRS-R) score has been widely used to assess the severity of major depression in children and adolescents; however, the clinical implications of changes in the CDRS-R score remain unclear. We evaluated these clinical implications by assessing the relationship between changes in the CDRS-R score and changes in the Clinical Global Impression of Improvement (CGI-I), in clinical research on major depression.
We used data from four clinical trials involving two antidepressants and evaluated the relationship between CDRS-R score changes and the CGI-I score using the equipercentile linking method.
CDRS-R score changes corresponding to a minimally improved (score of 3) CGI-I score was approximately 14 points.
Our findings from the linking analyses are useful for interpreting the clinical implications of changes in the CDRS-R score.