Planar cell polarity signaling: the developing cell's compass

Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue grad...

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Bibliographic Details
Published in:	Cold Spring Harbor perspectives in biology Vol. 1; no. 3; p. a002964
Main Authors:	Vladar, Eszter K, Antic, Dragana, Axelrod, Jeffrey D
Format:	Journal Article
Language:	English
Published:	United States Cold Spring Harbor Laboratory Press 01-09-2009
Subjects:	Animals Body Patterning Cell Division Cell Movement Cell Polarity Cilia - metabolism Cytoskeleton - metabolism Developmental Biology - methods Drosophila Humans Mice Models, Biological Models, Genetic Mutation Signal Transduction
Online Access:	Get full text
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Summary:	Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream system amplifies subcellular asymmetry and communicates polarity between cells. In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1943-0264 1943-0264
DOI:	10.1101/cshperspect.a002964