Changes in Behavior and Blood Corticosterone Level in Male and Female Rats after Single Administration of Obestatin Fragment 1-4

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 2; pp. 218 - 220
• Main Authors: Motorykina, E. S., Khirazova, E. A., Maslova, M. V., Graf, A. V., Maklakova, A. S., Bayzhumanov, A. A., Kurko, O. D., Andreeva, L. A., Sokolova, N. A., Myasoedov, N. F., Kamenskii, A. A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-06-2016; Springer; Springer Nature B.V
• Subjects: Animal behavior; Animals; Anti-Obesity Agents - pharmacology; Biomedical and Life Sciences; Biomedicine; Body weight; Cell Biology; Corticosterone; Corticosterone - blood; Female; Internal Medicine; Laboratory Medicine; Male; Maze Learning; Oligopeptides - pharmacology; Pathology; Peptides; Rats, Wistar; Risk-Taking; Steroids (Organic compounds); Stress, Psychological - blood; stress; obestatin; corticosterone; regulatory peptides; animal behavior
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3379-1

Single administration of the obestatin fragment 1-4 (300 nmol/kg) to male Wistar rats produced a significant weight loss in male rats on observation days 5-8, while in female rats only on day 8. In addition, males demonstrated decreased risk factor in the elevated plus-maze test, but no effect of the preparation on behavior of female rats was revealed. Obestatin fragment 1-4 had no effect on corticosterone level 1 week after single administration in both females and male rats.