LINC00665 promotes breast cancer progression through regulation of the miR-379-5p/LIN28B axis

• Published in: Cell death & disease Vol. 11; no. 1; pp. 16 - 11
• Main Authors: Ji, Wei, Diao, Yu-Ling, Qiu, Yi-Ran, Ge, Jie, Cao, Xu-Chen, Yu, Yue
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06-01-2020; Springer Nature B.V
• Subjects: 13/1; 13/109; 14/32; 38/1; 42/89; 631/337/384/2568; 64/60; 692/699/67/1347; 82/51; Antibodies; Base Sequence; Biochemistry; Biomedical and Life Sciences; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cell Biology; Cell Culture; Cell Line, Tumor; Cell migration; Cell proliferation; Disease Progression; Epithelial-Mesenchymal Transition - genetics; Female; Gene Expression Regulation, Neoplastic; Humans; Immunology; Life Sciences; Mesenchyme; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Models, Biological; Phenotype; Phenotypes; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Tumorigenesis
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/s41419-019-2213-x

Breast cancer is the most common malignant tumor among women worldwide. Although increasing evidence indicates that long noncoding RNAs (lncRNAs) play critical roles during breast tumorigenesis and progression, the involvement of most lncRNAs in breast cancer remains largely unknown. In the current study, we demonstrated that LINC00665 promotes breast cancer cell proliferation, migration, and invasion. Accumulating evidence indicates that many lncRNAs can function as endogenous miRNA sponges by competitively binding common miRNAs. In this study, we demonstrated that LINC00665 functions as a sponge for miR-379-5p, reducing the ability of miR-379-5p to repress LIN28B. LINC00665 promoted breast cancer progression and induced an epithelial–mesenchymal transition-like phenotype via the upregulation of LIN28B expression. Clinically, LINC00665 expression was increased but miR-379-5p expression was decreased in breast cancer tissues compared with that in normal breast tissues in the TCGA database. Furthermore, the expression of LINC00665 was negatively related with miR-379-5p expression. Collectively, our results reveal the LINC00665–miR-379-5p–LIN28B axis and shed light on breast cancer therapy.