Aberrant salience correlates with psychotic dimensions in outpatients with schizophrenia spectrum disorders

• Published in: Annals of general psychiatry Vol. 21; no. 1; pp. 1 - 25
• Main Authors: Pugliese, Valentina, de Filippis, Renato, Aloi, Matteo, Rotella, Paola, Carbone, Elvira Anna, Gaetano, Raffaele, De Fazio, Pasquale
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 03-07-2022; BioMed Central; BMC
• Subjects: Aberrant salience; Affective disorders; Alogia; Analysis; Antipsychotics; Cognition & reasoning; Cognitive ability; Correlation analysis; Delusions; Development and progression; Emotional behavior; Emotions; Environmental factors; Hallucinations; Influence; Intellectual disabilities; Mental disorders; Methods; Negative symptoms; Positive symptoms; Postural mannerisms; Psychology, Pathological; Psychopathology; Psychosis; Psychotropic drugs; Remission; Remission (Medicine); Schizophrenia; Social interactions; Social research; Social withdrawal; Stimulus salience; Withdrawal; Italy
• ISSN: 1744-859X; 1744-859X
• DOI: 10.1186/s12991-022-00402-5

Background Aberrant salience is a well-known construct associated with the development and maintenance of psychotic symptoms in schizophrenia. However, only a few studies have investigated aberrance salience as a trait, with no study investigating the association between the five aberrant salience domains and psychotic symptoms. We aimed to explore the role of aberrant salience and its domains on psychotic dimensions in both clinically remitted and non-remitted patients. Methods A sample of 102 patients diagnosed with schizophrenia spectrum disorders was divided according to the Positive and Negative Syndrome Scale (PANSS) remission criteria into two groups: remitted and non-remitted. Differences regarding psychotic symptomatology assessed by the PANSS and aberrant salience measured by the Aberrant Salience Inventory (ASI) were explored. Finally, a correlation analysis between the PANSS and the ASI was run. Results Significantly higher ASI scores were evident among non-remitted patients. Positive symptoms (i.e. delusions, conceptual disorganization, and hallucinatory behaviour) and general psychopathology (i.e. postural mannerisms, unusual thought content) were correlated to the aberrant salience subscales 'sharpening of senses', 'heightened emotionality' and 'heightened cognition' and with the ASI total score. Significant correlations emerged between negative symptoms (blunted affect and social withdrawal) and 'heightened cognition'. Finally, lack of spontaneity of conversation was related to the subscales 'heightened emotionality' and 'heightened cognition', as well as to the ASI total score. Conclusions These preliminary results support the hypothesis of an association between aberrant salience and psychotic symptoms in schizophrenia. Further research is needed, especially into the mechanisms underlying salience processing, in addition to social and environmental factors and cognitive variables. Keywords: Aberrant salience, Negative symptoms, Positive symptoms, Postural mannerisms, Social withdrawal, Alogia, Blunted affect, Delusions, Disorganization, Schizophrenia