Treatment failure in Haemophilus influenzae due to a beta-lactamase low-level ampicillin-resistant organism

• Published in: The Journal of infection Vol. 57; no. 6; pp. 485 - 488
• Main Authors: van der Ploeg, Vishnu, Gelinck, Luc B.S, Jonkers, Iris J.A.M, Mourer, Jacqueline S, van Dam, Alje P
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01-12-2008; Elsevier
• Subjects: Aged; Amoxicillin - therapeutic use; Ampicillin Resistance; Anti-Bacterial Agents - therapeutic use; beta-Lactamases - biosynthesis; Biological and medical sciences; BLNAR; General aspects; Haemophilus Infections - drug therapy; Haemophilus Infections - microbiology; Haemophilus influenzae; Haemophilus influenzae - drug effects; Haemophilus influenzae - enzymology; Haemophilus influenzae - isolation & purification; Humans; Infectious Disease; Infectious diseases; Male; Medical sciences; Non-typeable; Osteomyelitis - drug therapy; Osteomyelitis - microbiology; Spondylitis; Treatment Failure; Vertebral osteomyelitis; BLNAR; Spondylitis; Non-typeable; Haemophilus influenzae; Vertebral osteomyelitis; Pasteurellaceae; Infection; Treatment; Enzyme; Bacteria; Hydrolases; β-Lactamase; Failure
• ISSN: 0163-4453; 1532-2742
• DOI: 10.1016/j.jinf.2008.06.024

Summary Haemophilus influenzae is a rare causative organism of vertebral osteomyelitis in an adult. Cases reported in the literature were mainly caused by ampicillin-susceptible type b strains. Here we describe the first case of vertebral osteomyelitis due to a non-typeable, beta-lactamase low-level ampicillin-resistant H. influenzae strain with failure of prolonged intravenous amoxicillin treatment.