Immature Platelet Count Levels as a Novel Quality Marker in Plateletpheresis

• Published in: Indian journal of hematology & blood transfusion Vol. 34; no. 4; pp. 684 - 690
• Main Authors: Unay Demirel, Ozlem, Ignak, Seyda, Buyukuysal, Mustafa Cagatay
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01-10-2018; Springer Nature B.V
• Subjects: Automation; Biomarkers; Blood platelets; Blood Transfusion Medicine; Hematology; Human Genetics; Medicine; Medicine & Public Health; Oncology; Original; Original Article; Quality; Complete blood count; Reticulated platelets; Platelet indices; Plateletpheresis
• ISSN: 0971-4502; 0974-0449; 0974-0449; 0971-4502
• DOI: 10.1007/s12288-018-0965-6

The efficiency of plateletpheresis was improved owing to new developments in automated cell separators in the past decades. Nowadays multiple units of plateletpheresis products can be taken per collection from single donor and new parameters such as immature platelet fraction (IPF), immature platelet count (IPC) can be detected practically by automated hematology analyzers. Our aim is to find out a new quality parameter for evaluation of plateletpheresis by analyzing the platelet indices of donor and also to predict platelet recovery in recipients thereby preventing unnecessary platelet transfusion. In this study 104 platelet apheresis procedures were performed on the Trima Accel cell separator. Complete blood counts of donors and recipients were analyzed by Sysmex XN-1000 automated blood cell counter by means of quality parameters such as platelet count, IPF, IPC, mean platelet volume, platelet distribution width. We analyzed these parameters in the follow up after the transfusion of plateletpheresis and evaluated them as quality markers in the assessment of plateletpheresis effectiveness. For recipients of both single and double unit apheresis platelet transfusions, the pre-apheresis donor IPC correlated significantly with 1st and 24th hour recipient IPC values (
p
values < 0.05 for all comparisons). A-IPC as well as % change in IPF can be used to determine the quality of plateletpheresis in conjunction with platelet number in terms of evaluation of donors and also in the follow up of recipients undergoing platelet transfusion.