Facile Synthesis of Bio-Antimicrobials with “Smart” Triiodides

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 12; p. 3553
• Main Authors: Edis, Zehra, Bloukh, Samir Haj
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 10-06-2021; MDPI
• Subjects: Acids; Aloe vera; Antibiotics; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; antimicrobial resistance; Biofilms; Biomaterials; Biomedical materials; Coronaviruses; COVID-19; Discoloration; Disinfectants; Drug resistance; Flavonoids; Fourier analysis; Fourier transforms; Fungicides; Gentamicin; halogen bonding; Hybrids; Infrared analysis; Infrared spectroscopy; Iodine; Irritation; Microorganisms; Microstructural analysis; Multidrug resistance; Nanoparticles; Nosocomial infections; Nystatin; Pathogens; Phytochemicals; Plant extracts; Polyphenols; Polyvinylpyrrolidone; Raman spectroscopy; Salva officinalis L; Scanning electron microscopy; Skin; Spectroscopic analysis; Spectrum analysis; Stabilizers (agents); Surgical site infections; Sutures; triiodides
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26123553

Multi-drug resistant pathogens are a rising danger for the future of mankind. Iodine (I2) is a centuries-old microbicide, but leads to skin discoloration, irritation, and uncontrolled iodine release. Plants rich in phytochemicals have a long history in basic health care. Aloe Vera Barbadensis Miller (AV) and Salvia officinalis L. (Sage) are effectively utilized against different ailments. Previously, we investigated the antimicrobial activities of smart triiodides and iodinated AV hybrids. In this work, we combined iodine with Sage extracts and pure AV gel with polyvinylpyrrolidone (PVP) as an encapsulating and stabilizing agent. Fourier transform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV-Vis), Surface-Enhanced Raman Spectroscopy (SERS), microstructural analysis by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-Ray-Diffraction (XRD) analysis verified the composition of AV-PVP-Sage-I2. Antimicrobial properties were investigated by disc diffusion method against 10 reference microbial strains in comparison to gentamicin and nystatin. We impregnated surgical sutures with our biohybrid and tested their inhibitory effects. AV-PVP-Sage-I2 showed excellent to intermediate antimicrobial activity in discs and sutures. The iodine within the polymeric biomaterial AV-PVP-Sage-I2 and the synergistic action of the two plant extracts enhanced the microbial inhibition. Our compound has potential for use as an antifungal agent, disinfectant and coating material on sutures to prevent surgical site infections.