A comparison of low dose hyperbaric levobupivacaine and hypobaric levobupivacaine in unilateral spinal anaesthesia

• Published in: Anaesthesia and intensive care Vol. 38; no. 6; pp. 1002 - 1007
• Main Authors: KAYA, M, ÖZTLÜRK, I, TUNCEL, G, SENEL, G. Özalp, ESKICIRAK, H, KADIOGULLARI, N
• Format: Journal Article
• Language: English
• Published: Edgecliff Anaesthesia Society of Anaesthetists 01-11-2010; Sage Publications Ltd. (UK); Sage Publications Ltd
• Subjects: Adult; Anesthesia; Anesthesia, Spinal - methods; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Local - administration & dosage; Biological and medical sciences; Bupivacaine - administration & dosage; Bupivacaine - analogs & derivatives; Clinical trials; Comparative analysis; Dosage and administration; Female; Humans; Levobupivacaine; Male; Medical sciences; Middle Aged; Patient outcomes; United Kingdom; Local anesthetic; hyperbaric; spinal anaesthesia; Low dose; Levobupivacaine; Carboxamide; Anesthesia; Organic amide; unilateral; hypobaric; Comparative study
• ISSN: 0310-057X; 1448-0271
• DOI: 10.1177/0310057X1003800606

The aim of this study was to compare the clinical effects and characteristics of hyperbaric and hypobaric levobupivacaine for unilateral spinal anaesthesia. Sixty patients were randomly allocated into two groups to receive either 7.5 mg (1.5 ml) hyperbaric levobupivacaine 0.5% or 7.5 mg (4 ml) hypobaric levobupivacaine 0.1875% for elective arthroscopic surgery of the knee under spinal anaesthesia. The level and duration of sensory block, intensity and duration of motor block were recorded. Unilateral sensory block was observed in 27 patients (90%) in the hyperbaric group and 24 patients (80%) in the hypobaric group in the lateral position. After 15 minutes, patients were turned to supine to redistribute the spinal block toward the non-operative side, but spinal anaesthesia was still unilateral in 18 patients (60%) in the hyperbaric group and 10 patients (33%) in the hypobaric group (P = 0.038). Time to readiness for home discharge and complete recovery of sensory block were similar in both groups. In the hyperbaric group, the motor block scores were higher on the operative side during first 10 minutes than they were in the hypobaric group (P < 0.002). Motor block regression was faster in the hyperbaric group (P = 0.01). Hyperbaric and hypobaric levobupivacaine both provided satisfactory unilateral spinal anaesthesia with good haemodynamic stability for arthroscopic surgery, but with more frequent unilateral spinal anaesthesia in the hyperbaric group.