The association between enteral nutrition with survival of critical patients with COVID‐19

• Published in: Immunity, Inflammation and Disease Vol. 12; no. 5; pp. e1261 - n/a
• Main Authors: Gholamalizadeh, Maryam, Salimi, Zahra, Mobarakeh, Khadijeh Abbasi, Mahmoudi, Zahra, Tajadod, Shirin, Mousavi Mele, Mahdi, Alami, Farkhondeh, Bahar, Bojlul, Doaei, Saeid, Khoshdooz, Sara, Rahvar, Masoume, Gholami, Somayeh, Pourtaleb, Masoume
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-05-2024; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Aged; Body mass index; Case-Control Studies; Chronic illnesses; COVID-19; COVID-19 - mortality; COVID-19 - therapy; Critical Illness - mortality; Enteral Nutrition; Female; Humans; Intensive Care Units - statistics & numerical data; Male; Middle Aged; Mortality; Nutrition; Original; SARS-CoV-2; survival; enteral nutrition; mortality; COVID‐19; survival
• ISSN: 2050-4527; 2050-4527
• DOI: 10.1002/iid3.1261

Background
Coronavirus disease 2019 (COVID‐19) results in several complications and mortality in intensive care unit (ICU) patients. Limited studies have investigated the effect of enteral nutrition (EN) on the survival of COVID‐19 patients in the ICU. The aim of this study was to investigate the association of EN with biochemical and pathological indices associated with mortality in ICU patients with COVID‐19.
Methods
This case–control study was conducted on 240 patients with COVID‐19 hospitalized in the ICU including 120 eventual nonsurvived as the cases and 120 survived patients as the controls. All of the patients received EN as a high protein high volume or standard formula. Data on general information, anthropometric measurements, and the results of lab tests were collected.
Results
The recovered patients received significantly more high protein (60.8% vs. 39.6%, p = .004) and high volume (61.6% vs. 42.3%, p = .005) formula compared to the nonsurvived group. Mortality was inversely associated with high volume (odds ratio [OR]: 0.45 confidence interval [CI]95%, p = .008) and high protein (OR: 0.42 CI95%, p = .003) formula. The results remained significant after adjusting for age and sex. Further adjustment for underlying diseases, smoking, body mass index, and the acute physiology and chronic health evaluation II (APACHE II) score did not change the results.
Conclusion
The findings of the study showed that there was a significant inverse association between mortality and high volume and high protein formula in patients with COVID‐19. Further investigation is warranted.
Characteristics of the coronavirus disease 2019 participants recovered and died after hospitalization intensive care unit.