Retroviral Danger from Within: TLR7 Is in Control

Retroviral Danger from Within: TLR7 Is in Control

In this issue of Immunity, Yu et al. (2012) outline a fascinating model in which TLR7-mediated antibody production acts as a dominant immunosurveillance mechanism against endogenous retroviruses (ERVs), with additional support of TLR3 and TLR9 that function to prevent ERV-mediated malignancy.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Vol. 37; no. 5; pp. 763 - 766
Main Authors: Mankan, Arun K., Hornung, Veit
Format: Journal Article
Language:English
Published: United States Elsevier Inc 16-11-2012
Elsevier Limited
Subjects:
Cytotoxicity
Gene expression
Immune system
Leukemia
Lymphocytes
Mutation
Propagation
Retroviridae
Rodents
Studies
Viruses
Online Access:Get full text
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Description
Summary:In this issue of Immunity, Yu et al. (2012) outline a fascinating model in which TLR7-mediated antibody production acts as a dominant immunosurveillance mechanism against endogenous retroviruses (ERVs), with additional support of TLR3 and TLR9 that function to prevent ERV-mediated malignancy.
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2012.10.009