Polyacrylamide Ferrogels with Magnetite or Strontium Hexaferrite: Next Step in the Development of Soft Biomimetic Matter for Biosensor Applications

• Published in: Sensors (Basel, Switzerland) Vol. 18; no. 1; p. 257
• Main Authors: Safronov, Alexander P, Mikhnevich, Ekaterina A, Lotfollahi, Zahra, Blyakhman, Felix A, Sklyar, Tatyana F, Larrañaga Varga, Aitor, Medvedev, Anatoly I, Fernández Armas, Sergio, Kurlyandskaya, Galina V
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16-01-2018; MDPI
• Subjects: Acrylamide; Biocompatibility; Biomedical materials; Biomimetics; Biosensors; Deformation; ferrofluids; ferrogel; Free radical polymerization; Gels; giant magnetoimpedance; Guar gum; magnetic biosensors; Magnetic fields; Magnetic materials; magnetic nanoparticles; Magnetic properties; Magnetism; Magnetite; Magnetoimpedance; Mechanical properties; Modulus of elasticity; polyacrylamide gel; Strontium; strontium hexaferrite; Thickeners; Tissue engineering; Xanthan; magnetite; tissue engineering; giant magnetoimpedance; magnetic biosensors; strontium hexaferrite; ferrofluids; polyacrylamide gel; magnetic nanoparticles; ferrogel
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s18010257

Magnetic biosensors are an important part of biomedical applications of magnetic materials. As the living tissue is basically a "soft matter." this study addresses the development of ferrogels (FG) with micron sized magnetic particles of magnetite and strontium hexaferrite mimicking the living tissue. The basic composition of the FG comprised the polymeric network of polyacrylamide, synthesized by free radical polymerization of monomeric acrylamide (AAm) in water solution at three levels of concentration (1.1 M, 0.85 M and 0.58 M) to provide the FG with varying elasticity. To improve FG biocompatibility and to prevent the precipitation of the particles, polysaccharide thickeners-guar gum or xanthan gum were used. The content of magnetic particles in FG varied up to 5.2 wt % depending on the FG composition. The mechanical properties of FG and their deformation in a uniform magnetic field were comparatively analyzed. FG filled with strontium hexaferrite particles have larger Young's modulus value than FG filled with magnetite particles, most likely due to the specific features of the adhesion of the network's polymeric subchains on the surface of the particles. FG networks with xanthan are stronger and have higher modulus than the FG with guar. FG based on magnetite, contract in a magnetic field 0.42 T, whereas some FG based on strontium hexaferrite swell. Weak FG with the lowest concentration of AAm shows a much stronger response to a field, as the concentration of AAm governs the Young's modulus of ferrogel. A small magnetic field magnetoimpedance sensor prototype with Co
Fe
Mo
Si
B
rapidly quenched amorphous ribbon based element was designed aiming to develop a sensor working with a disposable stripe sensitive element. The proposed protocol allowed measurements of the concentration dependence of magnetic particles in gels using magnetoimpedance responses in the presence of magnetite and strontium hexaferrite ferrogels with xanthan. We have discussed the importance of magnetic history for the detection process and demonstrated the importance of remnant magnetization in the case of the gels with large magnetic particles.