Manadodioxans A−E: polyketide endoperoxides from the marine sponge Plakortis bergquistae

Manadodioxans A−E: polyketide endoperoxides from the marine sponge Plakortis bergquistae

Five new polyketide endoperoxides, manadodioxans A−E, were isolated from the marine sponge Plakortis bergquistae. Manadodioxan E showed antimicrobial activity against Escherichia coli at 10 μg/disk, while its oxo congener, manadodioxan D, was inactive.

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Bibliographic Details
Published in:Journal of natural medicines Vol. 69; no. 4; pp. 595 - 600
Main Authors: Gushiken, Masaki, Kagiyama, Ippei, Kato, Hikaru, Kuwana, Toshiyuki, Losung, Fitje, Mangindaan, Remy E. P, de Voogd, Nicole J, Tsukamoto, Sachiko
Format: Journal Article
Language:English
Published: Tokyo Springer Japan 01-10-2015
Subjects:
Animals
Anti-Infective Agents - chemistry
anti-infective properties
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Escherichia coli
Medicinal Chemistry
Pharmacology/Toxicology
Pharmacy
Plakortis - chemistry
Plant Sciences
Plants, Medicinal
Polyketides - chemistry
Porifera
Porifera - chemistry
Antimicrobial
Marine sponge
Polyketide endoperoxides
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Description
Summary:Five new polyketide endoperoxides, manadodioxans A−E, were isolated from the marine sponge Plakortis bergquistae. Manadodioxan E showed antimicrobial activity against Escherichia coli at 10 μg/disk, while its oxo congener, manadodioxan D, was inactive.
Bibliography:http://dx.doi.org/10.1007/s11418-015-0920-x
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-015-0920-x