Orexins and their receptors from fish to mammals: A comparative approach

• Published in: General and comparative endocrinology Vol. 171; no. 2; pp. 124 - 130
• Main Authors: Wong, Kari K.Y, Ng, Stephanie Y.L, Lee, Leo T.O, Ng, Hans K.H, Chow, Billy K.C
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-04-2011
• Subjects: Amino Acid Sequence; Animals; Brain - metabolism; endocrinology; Endocrinology & Metabolism; energy intake; energy metabolism; Evolution; Evolution, Molecular; fish; Fishes - genetics; Fishes - metabolism; food intake; hypothalamus; Intracellular Signaling Peptides and Proteins - chemistry; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; invertebrates; mammals; Mammals - genetics; Mammals - metabolism; Molecular Sequence Data; neurons; neuropeptides; Neuropeptides - chemistry; Neuropeptides - genetics; Neuropeptides - metabolism; Orexin; Orexin receptor; Orexin Receptors; Orexins; receptors; Receptors, G-Protein-Coupled - chemistry; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Receptors, Neuropeptide - chemistry; Receptors, Neuropeptide - genetics; Receptors, Neuropeptide - metabolism; reproduction; Sequence Homology, Amino Acid; sleep; Orexin receptor; Evolution; Orexin
• ISSN: 0016-6480; 1095-6840
• DOI: 10.1016/j.ygcen.2011.01.001

Research highlights ► Orexins’ are under strong evolutionary pressure to preserve structure and functions. ► OX2R is evolutionary more ancient. ► OX1R likely evolved by gene duplication after the divergence giving rise to mammals. ► Orexins’ are functionally important in regulating physiological processes