Course of vasopressin and copeptin plasma concentrations in a patient with severe septic shock

In this case report, the course of arginine vasopressin and copeptin, the stable C-terminal part of the arginine vasopressin precursor, is described during the period of critical illness in a septic shock patient. Arginine vasopressin and copeptin concentrations were substantially increased during t...

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Bibliographic Details
Published in:	Anaesthesia and intensive care Vol. 34; no. 4; pp. 498 - 500
Main Authors:	JOCHBERGER, S, LUCKNER, G, MAYR, V. D, WENZEL, V, MORGENTHALER, N. G, FRIESENECKER, B. E, HASIBEDER, W. R, DÜNSER, M. W
Format:	Journal Article
Language:	English
Published:	Edgecliff Anaesthesia and Intensive Care 01-08-2006 Sage Publications Ltd. (UK) Sage Publications Ltd
Subjects:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arginine Vasopressin - blood Biological and medical sciences Chronic Disease Critical Care Glycopeptides - blood Hemodynamics - physiology Humans Hypertension - complications Intestinal Perforation - complications Male Medical sciences Middle Aged Peritonitis - complications Shock, Septic - blood Shock, Septic - etiology Shock, Septic - microbiology Streptococcal Infections - blood Streptococcal Infections - etiology Streptococcal Infections - microbiology Streptococcus milleri Group Shock Human copeptin septic shock Vasopressin Infection Sepsis syndrome plasma concentrations arginine vasopressin Arginine Aminoacid Anesthesia sepsis
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Summary:	In this case report, the course of arginine vasopressin and copeptin, the stable C-terminal part of the arginine vasopressin precursor, is described during the period of critical illness in a septic shock patient. Arginine vasopressin and copeptin concentrations were substantially increased during the initial 36 hours of shock. Subsequently, both hormones continuously decreased, but exhibited another peak in response to stress during extubation. During restoration of cardiovascular stability, endogenous arginine vasopressin levels further decreased and obviously did not contribute to haemodynamic improvement. In contrast, the decrease in arginine vasopressin and copeptin can be at least partly explained by an improvement of cardiovascular function.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0310-057X 1448-0271
DOI:	10.1177/0310057x0603400415