Sequences of memory-guided saccades in Parkinson's disease

Sequences of memory-guided saccades in Parkinson's disease

Sequences of ocular saccades were studied in 8 patients with Parkinson's disease, with (i.e., "on") and without (i.e., "off") levodopa treatment. The amplitude of single saccades was decreased and not improved by treatment. The chronology of saccades during sequences was imp...

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Bibliographic Details
Published in:Annals of neurology Vol. 35; no. 4; p. 487
Main Authors: Vermersch, A I, Rivaud, S, Vidailhet, M, Bonnet, A M, Gaymard, B, Agid, Y, Pierrot-Deseilligny, C
Format: Journal Article
Language:English
Published: United States 01-04-1994
Subjects:
Electrooculography
Humans
Memory - physiology
Middle Aged
Parkinson Disease - physiopathology
Photic Stimulation
Reaction Time - physiology
Saccades - physiology
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Summary:Sequences of ocular saccades were studied in 8 patients with Parkinson's disease, with (i.e., "on") and without (i.e., "off") levodopa treatment. The amplitude of single saccades was decreased and not improved by treatment. The chronology of saccades during sequences was impaired in patients in the "off" state, but significantly improved during the "on" period. These results are compatible with a decreased activation of the supplementary motor area, which can be reversed by levodopa.
ISSN:0364-5134
DOI:10.1002/ana.410350419