Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes

• Published in: Acta neurologica Scandinavica Vol. 123; no. 2; pp. 105 - 110
• Main Authors: They-They, T. P., Nadifi, S., Rafai, M. A., Battas, O., Slassi, I.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-02-2011; Blackwell
• Subjects: Adult; Age Factors; Aged; atherothrombosis; Biological and medical sciences; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease - genetics; Genotype; Humans; Indexing in process; ischemic stroke; Male; Medical sciences; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Moroccan population; MTHFR polymorphism; Neurology; Polymorphism, Single Nucleotide - genetics; Risk Factors; Sex Factors; Stroke - classification; Stroke - genetics; Cerebral infarction; Stroke; Nervous system diseases; Enzyme; MTHFR polymorphism; atherothrombosis; Cardiovascular disease; Artery; Cerebral disorder; Vascular disease; Blood vessel; Moroccan population; Central nervous system disease; Brain ischemia; Circulatory system; Oxidoreductases; Subtype; Cerebrovascular disease; ischemic stroke; Polymorphism; Reductase
• ISSN: 0001-6314; 1600-0404
• DOI: 10.1111/j.1600-0404.2010.01348.x

They‐They TP, Nadifi S, Rafai MA, Battas O, Slassi I. Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes.
Acta Neurol Scand: 2011: 123: 105–110.
© 2010 John Wiley & Sons A/S.
Background –  The role for the methylenetetrahydrofolate reductase C677T gene variants in the risk of ischemic stroke is controversial.
Method –  This first case–control study including 91 cases affected by ischemic stroke and 182 controls matched for age, sex, and same area was conducted in Casablanca, Morocco. Allele and genotype frequency were characterized by using PCR followed by HinfI enzymatic digestion.
Results –  We found no statistic association of T allele carriers genetic factors with stroke; odds ratio, 1.1; 95% confidence interval (CI), 0.59–2.04, P = 0.303. The results shown significant association of T allele carriers genetic factors with atherothrombotic subtype stroke (n = 42); odds ratio, 2.1; 95% CI: 1.17–3.8; P = 0.012, and adjusted odds ratio of 6.5; 95% CI: 1.86–23.1, P = 0.003, for TT genotype variant compared with CC wild genotype.
Conclusion –  We suggested that MTHFR C677T variant may be a determinant of atherothrombotic event of ischemic stroke in Morocco.