Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders

• Published in: International journal of molecular sciences Vol. 18; no. 2; p. 316
• Main Authors: Woo, Yu Ri, Hwang, Sewon, Jeong, Seo Won, Cho, Dae Ho, Park, Hyun Jeong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03-02-2017; MDPI
• Subjects: Alopecia; Alopecia - diagnosis; Alopecia - genetics; Alopecia - metabolism; Biomarkers; Case-Control Studies; Communication; Differentiation; Down-Regulation; Epidermis; Epidermis - metabolism; Epidermis - pathology; Epithelium - metabolism; Epithelium - pathology; erythroid differentiation regulator 1; Follicles; Gene Expression; Hair; Hair Follicle - metabolism; Hair loss; Humans; Immune system; Immunohistochemistry; Inflammation; Membrane Proteins - genetics; Membrane Proteins - metabolism; Pathogenesis; Patients; Psoriasis; Rosacea; Skin; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; erythroid differentiation regulator 1; hair loss; alopecia; inflammation
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms18020316

Erythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss disorders and five control subjects were retrieved, in order to assess their expression levels of Erdr1. Results revealed that expression of Erdr1 was significantly downregulated in the epidermis and hair follicles of patients with hair loss disorders, when compared to that in the control group. In particular, the expression of Erdr1 was significantly decreased in patients with alopecia areata. We propose that Erdr1 downregulation might be involved in the pathogenesis of hair loss, and could be considered as a novel biomarker for hair loss disorders.