Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status

• Published in: The pharmacogenomics journal Vol. 5; no. 1; pp. 30 - 34
• Main Authors: Almeida, S, Franken, N, Zandoná, M R, Osório-Wender, M C, Hutz, M H
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01-01-2005
• Subjects: Adult; Aged; Contraceptives, Oral, Hormonal - pharmacology; Contraceptives, Oral, Hormonal - therapeutic use; Cross-Sectional Studies; Estrogen Receptor beta - genetics; Estrogen receptors; Estrogens; Female; Gene polymorphism; Genotype & phenotype; Hormone replacement therapy; Humans; Lipid metabolism; Lipids - blood; Lipids - genetics; Low density lipoprotein; Middle Aged; Polymorphism, Genetic - drug effects; Polymorphism, Genetic - genetics; Post-menopause; Postmenopause - blood; Postmenopause - drug effects; Postmenopause - genetics; Premenopause - blood; Premenopause - drug effects; Premenopause - genetics; Progesterone; Receptors, Progesterone - genetics; Single-nucleotide polymorphism; Steroid hormones
• ISSN: 1470-269X; 1473-1150
• DOI: 10.1038/sj.tpj.6500272

Sex steroid hormones have multiple effects on lipid metabolism. We investigated the association between two common single nucleotide polymorphisms of the estrogen receptor 2 gene (ESR2), 1082G>A and 1730A>G, and PROGINS polymorphism of the progesterone receptor gene (PGR) with lipoprotein levels in a cross-sectional study with 472 women of European descent. The women were classified into three subgroups according to hormonal status, premenopausal women (n=187; mean age=34+/-9.7 years), postmenopausal women exposed to hormone replacement therapy (HRT) (n=118; 56+/-6.7 years) and postmenopausal women unexposed to HRT (n=167; 58+/-9.8 years). The premenopausal and postmenopausal women exposed to HRT, both carriers of G/A genotype, exhibited LDL-C (P=0.027 and 0.001, respectively) and T-chol levels (P=0.035 and 0.001, respectively) lower than carriers of G/G genotype. This association was not observed in postmenopausal women unexposed to HRT. These results suggest that ESR2 1082G>A genotype may influence LDL-C levels in women with abundant estrogen levels, due to either endogenous or exogenous sources.