Postnatal development of GABAergic interneurons in the neocortical subplate of mice

• Published in: Neuroscience Vol. 322; pp. 78 - 93
• Main Authors: Qu, G.-J, Ma, J, Yu, Y.-C, Fu, Y
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 13-05-2016
• Subjects: Animals; Animals, Newborn; Calbindins - metabolism; Cell Count; GABAergic Neurons - cytology; GABAergic Neurons - physiology; Gene Knock-In Techniques; Glutamate Decarboxylase - genetics; Glutamate Decarboxylase - metabolism; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; interneuron; Interneurons - cytology; Interneurons - physiology; Mice, Transgenic; Neocortex - cytology; Neocortex - growth & development; Neocortex - metabolism; Neurology; Neuropeptide Y - metabolism; Nitric Oxide Synthase Type I - metabolism; Organ Size; Parvalbumins - metabolism; postnatal development; Receptors, GABA-A - metabolism; Receptors, Serotonin, 5-HT3 - genetics; Receptors, Serotonin, 5-HT3 - metabolism; Somatostatin - metabolism; subplate; subtype; medial ganglionic eminence; PV; neuropeptide Y; PFA; phosphate-buffered saline; postnatal development; caudal ganglionic eminence; MC; nuclear receptor-related 1; paraformaldehyde; PBS; Nurr1; DAPI; 4′,6-diamidino-2-phenylindole; VC; subplate; 5HT 3AR; γ-aminobutyric acid; layer 2 and Layer 3; GABA ARδ; nNOS; GABA; somatosensory cortex; vasoactive intestinal polypeptide; visual cortex; calbindin; SC; white matter; subtype; NPY; WM; layer 6; layer 5; calretinin; layer 4; layer 1; SP; CB; CGE; motor cortex; L1; L4; L2/3; L5; neuronal nitric oxide synthase; L6; MGE; CR; SOM; GABA-A receptor subunit delta; parvalbumin; somatostatin; interneuron; VIP; serotonin receptor 3A; 5HT3AR; GABAARδ
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2016.02.023

Graphical abstract Qu et al. described the molecular composition of subplate interneurons as well as their developmental profile and distribution in postnatal mice. Subplate interneurons comprise SOM+ , 5HT3A R+ , and PV+ non-overlapping subpopulations. SOM+ interneurons expressed NPY, nNOS and CB. 5HT3A R subplate interneurons are comprised of GABAA Rδ+ and CR+ subtypes. All PV+ interneurons expressed GABAA Rδ.