Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis

Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Ou...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 16; no. 24; pp. 2323 - 2325
Main Authors:	Zhang, Weiguo, Karpen, Gary H., Zhang, Qing
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 17-12-2017
Subjects:	Carcinogenesis CENP-A centromere Centromere Protein A - genetics Centromere Protein A - metabolism Chromosomal Instability chromosome instability Cyclin E1 DNA-Binding Proteins - metabolism Extra View F-Box-WD Repeat-Containing Protein 7 - metabolism FBW7 Humans Mutagenesis, Site-Directed Neoplasms - metabolism Neoplasms - pathology Phosphorylation tumorigenesis centromere tumorigenesis FBW7 CENP-A Cyclin E1 chromosome instability
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Summary:	Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.
ISSN:	1538-4101 1551-4005
DOI:	10.1080/15384101.2017.1387698