Dissociable cerebellar activity during spatial navigation and visual memory in bilateral vestibular failure

• Published in: Neuroscience Vol. 305; pp. 257 - 267
• Main Authors: Jandl, N.M, Sprenger, A, Wojak, J.F, Göttlich, M, Münte, T.F, Krämer, U.M, Helmchen, C
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01-10-2015
• Subjects: Adult; Aged; Analysis of Variance; bilateral vestibular failure; Brain Mapping; Case-Control Studies; cerebellum; Cerebellum - blood supply; Cerebellum - physiopathology; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Memory - physiology; Middle Aged; navigation; Neurology; Oxygen - blood; Photic Stimulation; Psychophysics; Space Perception; Spatial Navigation - physiology; Vestibular Diseases - pathology; Vestibular Diseases - physiopathology; Vestibular Evoked Myogenic Potentials - physiology; visual memory; CVS; NAV; MoCA; head impulse test; GLM; navigation trial; Vertigo Handicap Questionnaire; cerebellum; visual memory trial; Clinical Vestibular Score; SVV; navigation; FDR; qHIT; Subjective Dizziness Score; false discovery rate; quantitative head impulse test; MEMO; VHQ; SDS; visual memory; bilateral vestibular failure; vestibulo-ocular reflex; subjective visual vertical; ROI; general linear model; fMRI; HIT; BVF; region of interest; VSS; echo-planar imaging; VOR; vestibular evoked myogenic potentials; Vertigo Symptom Scale; VEMPs; functional magnetic resonance imaging; Montreal Cognitive Assessment test; EPI
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.07.089

Highlights • Spatial orientation and navigation depends on information from the vestibular system. • In this study, patients with bilateral vestibular failure did not differ in navigational performance from controls. • Groups did not differ in navigation-related activity in the hippocampus. • Patients showed higher cerebellar activity during spatial navigation than during visual memory tasks. • Cerebellar activity may be related to a change in navigational (from allocentric to sequence-based) strategy.