Spatial cognitive deficits in an animal model of Wernicke–Korsakoff syndrome are related to changes in thalamic VDAC protein concentrations

• Published in: Neuroscience Vol. 294; pp. 29 - 37
• Main Authors: Bueno, K.O, de Souza Resende, L, Ribeiro, A.F, dos Santos, D.M, Gonçalves, E.C, Vigil, F.A.B, de Oliveira Silva, I.F, Ferreira, L.F, de Castro Pimenta, A.M, Ribeiro, A.M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 21-05-2015
• Subjects: Animals; Cognition Disorders - metabolism; Disease Models, Animal; Korsakoff Syndrome - genetics; Korsakoff Syndrome - metabolism; Learning - physiology; Male; Neurology; proteomic; Proteomics - methods; rats; Rats, Wistar; Space Perception; spatial learning; thalamus; Thalamus - metabolism; thiamine deficiency; Thiamine Deficiency - genetics; VDAC; Voltage-Dependent Anion Channels - metabolism; IPG; PTD; internal medullary lamina; WE; immobilized pH gradient; Wernicke–Korsakoff syndrome; rats; Voltage-Dependent Anion Channels; polymerase chain reaction; pyrithiamine-induced TD; thalamus; Wernicke’s Encephalopathy; MWM; 2D SDS–PAGE; IML; thiamine deficiency; proteomic; spatial learning; TD; two-dimensional sodium dodecyl sulfate–polyacrylamide gel electrophoresis; VDACs; VDAC; ATN; anterior thalamic nuclei; Morris Water Maze; PCR; WKS
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.03.001

Highlights • TD affects spatial learning and increased and decreased thalamic protein levels. • Four thalamic protein changes are related to spatial cognitive performance of rats. • Changes in VDAC, one of the four proteins, relate to rats’ spatial learning. • The association of VDAC is evident in the session with the worst performance.