Host-parasite interactions during Plasmodium infection: Implications for immunotherapies

Malaria is a global infectious disease that remains a leading cause of morbidity and mortality in the developing world. Multiple environmental and host and parasite factors govern the clinical outcomes of malaria. The host immune response against the parasite is heterogenous and stage-specific both...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers in immunology Vol. 13; p. 1091961
Main Authors:	Chandley, Pankaj, Ranjan, Ravikant, Kumar, Sudhir, Rohatgi, Soma
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 04-01-2023
Subjects:	Animals antibody therapy host-directed therapy Host-Parasite Interactions Humans immune evasion Immunology immunotherapeutics Immunotherapy Malaria Parasites Plasmodium vaccine candidates Plasmodium host-directed therapy vaccine candidates immune evasion immunotherapeutics antibody therapy
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Malaria is a global infectious disease that remains a leading cause of morbidity and mortality in the developing world. Multiple environmental and host and parasite factors govern the clinical outcomes of malaria. The host immune response against the parasite is heterogenous and stage-specific both in the human host and mosquito vector. The parasite virulence is predominantly associated with its ability to evade the host's immune response. Despite the availability of drug-based therapies, parasites can acquire drug resistance due to high antigenic variations and allelic polymorphisms. The lack of licensed vaccines against infection necessitates the development of effective, safe and successful therapeutics. To design an effective vaccine, it is important to study the immune evasion strategies and stage-specific proteins, which are targets of the host immune response. This review provides an overview of the host immune defense mechanisms and parasite immune evasion strategies during infection. Furthermore, we also summarize and discuss the current progress in various anti-malarial vaccine approaches, along with antibody-based therapy involving monoclonal antibodies, and research advancements in host-directed therapy, which can together open new avenues for developing novel immunotherapies against malaria infection and transmission.
Bibliography:	Reviewed by: Manish Goyal, Boston University, United States; Rajni Kant Shukla, The Ohio State University, United States Edited by: Rahul Shivahare, The Ohio State University, United States This article was submitted to Parasite Immunology, a section of the journal Frontiers in Immunology
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2022.1091961