Single-Institution Experience with Matrix Coils in the Treatment of Intracranial Aneurysms: Comparison with Same-Center Outcomes with the Use of Platinum Coils

• Published in: American Journal of Neuroradiology Vol. 28; no. 9; pp. 1736 - 1742
• Main Authors: Rivet, D.J, Moran, C.J, Mazumdar, A, Pilgram, T.K, Derdeyn, C.P, Cross, D.T
• Format: Journal Article
• Language: English
• Published: Oak Brook, IL Am Soc Neuroradiology 01-10-2007; American Society of Neuroradiology
• Subjects: Biological and medical sciences; Electrodiagnosis. Electric activity recording; Embolization, Therapeutic - instrumentation; Embolization, Therapeutic - methods; Equipment Design; Equipment Failure Analysis; Female; Humans; Interventional; Intracranial Aneurysm - diagnostic imaging; Intracranial Aneurysm - therapy; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nervous system; Platinum; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiography; Retrospective Studies; Secondary Prevention; Treatment Outcome; Vascular disease; Intracranial; Experience; Nervous system diseases; Prognosis; Treatment; Radiodiagnosis; Platinum; Aneurysm; Cardiovascular disease; Comparative study; Coil
• ISSN: 0195-6108; 1936-959X; 1432-1920
• DOI: 10.3174/ajnr.A0633

This study was undertaken to analyze the outcomes and treatment-related complications of the polyglycolic/polylactic acid (PGLA)-coated Matrix platinum coils in the treatment of intracranial aneurysms and compare these results with those derived from the same single-institutional experience with use of uncoated, bare platinum coils.
In this study, we compared 2 groups of patients in a retrospective fashion. The first group consisted of 70 consecutive patients who underwent 82 aneurysm treatments with Matrix coils during the 14-month period of study, from January 2003 to February 2004. We compared this cohort with 70 consecutive patients who underwent a total of 80 aneurysm treatments with bare platinum coils in the 12 months immediately preceding the use of PGLA-coated coils, from January through December 2002. We then recorded the treatment characteristics, angiographic outcomes, and any complications.
There were similar baseline demographic characteristics between the 2 study groups except in age, anatomic location, and length of follow-up. The overall recurrence rate of aneurysms was 41% among the Matrix-treated group and 32% among the patients treated with bare platinum. Among the 42 patients treated with 100% Matrix, the rate of recurrence was 31%. Of the recurrences, 21% of the Matrix group, 19% of the 100% Matrix group, and 9% of the bare platinum group required retreatment. The overall rate of complications was 10% in the Matrix-treated group and 7% in the bare platinum group. There was not a statistically significant difference in the rate of recurrence of aneurysms or complications between the 2 groups.
On the basis of our single-center experience, there is insufficient evidence to support the use of Matrix coils over bare platinum coils, given their disadvantages.