Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2

• Published in: Scientific reports Vol. 11; no. 1; p. 12782
• Main Authors: Todo, Kenichi, Yoshimura, Shinichi, Uchida, Kazutaka, Yamagami, Hiroshi, Sakai, Nobuyuki, Kishima, Haruhiko, Mochizuki, Hideki, Ezura, Masayuki, Okada, Yasushi, Kitagawa, Kazuo, Kimura, Kazumi, Sasaki, Makoto, Tanahashi, Norio, Toyoda, Kazunori, Furui, Eisuke, Matsumaru, Yuji, Minematsu, Kazuo, Kitano, Takaya, Okazaki, Shuhei, Sasaki, Tsutomu, Sakaguchi, Manabu, Takagaki, Masatoshi, Nishida, Takeo, Nakamura, Hajime, Morimoto, Takeshi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17-06-2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/617; 692/617/375; 692/617/375/534; Age; Angioplasty; Cardiovascular system; Cerebral blood flow; Hospitals; Humanities and Social Sciences; Ischemia; Medicine; multidisciplinary; Neurology; Neurosurgery; Reperfusion; Review boards; Science; Science (multidisciplinary); Stroke; Tomography; Japan
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-92100-7

Early reperfusion after endovascular thrombectomy is associated with an improved outcome in ischemic stroke patients; however, the time dependency in elderly patients remains unclear. We investigated the time–outcome relationships in different age subgroups. Of 2420 patients enrolled in the RESCUE-Japan Registry 2 study, a study based on a prospective registry of stroke patients with acute cerebral large-vessel occlusion at 46 centers, we analyzed the data of 1010 patients with successful reperfusion after endovascular therapy (mTICI of 2b or 3). In 3 age subgroups (< 70, 70 to < 80, and ≥ 80 years), the mRS scores at 90 days were analyzed according to 4 categories of onset-to-reperfusion time (< 180, 180 to < 240, 240 to < 300, and ≥ 300 min). In each age subgroup, the distributions of mRS scores were better with shorter onset-to-reperfusion times. The adjusted common odds ratios for better outcomes per 1-category delay in onset-to-reperfusion time were 0.66 (95% CI 0.55–0.80) in ages < 70 years, 0.66 (95% CI 0.56–0.79) in ages 70 to < 80 years, and 0.83 (95% CI 0.70–0.98) in ages ≥ 80 years. Early reperfusion was associated with better outcomes across all age subgroups. Achieving early successful reperfusion is important even in elderly patients.