Excessive eccentric exercise leads to transitory hypothalamic inflammation, which may contribute to the low body weight gain and food intake in overtrained mice

• Published in: Neuroscience Vol. 311; pp. 231 - 242
• Main Authors: Pereira, B.C, da Rocha, A.L, Pauli, J.R, Ropelle, E.R, de Souza, C.T, Cintra, D.E, Sant’Ana, M.R, da Silva, A.S.R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 17-12-2015
• Subjects: Animals; Body Weight - physiology; Cytokines - metabolism; Eating - physiology; eccentric exercise; Hand Strength - physiology; hypothalamus; Hypothalamus - immunology; inflammation; Inflammation - metabolism; Leptin - metabolism; Male; Mice, Inbred C57BL; Motor Activity - physiology; Muscle, Skeletal - immunology; Neurology; overtraining; Random Allocation; Rotarod Performance Test; Running - physiology; Sedentary Lifestyle; suppressor of cytokine signaling 3; IL-1beta; IκB kinase; ILT; interleukin 6; SOCS3; SE; Tris-buffered saline; analysis of variance; incremental load test; ANOVA; inflammation; Janus kinase 2; ethylenediaminetetraacetic acid; intracerebroventricular; overtraining; JAK2; exhaustion velocity; interleukin 10; eccentric exercise; stress-activated protein kinases/Jun amino-terminal kinases; TBS; STAT3; FOR; IKK; signal transducer and activator of transcription 3; interleukin 1beta; EDTA; standard error; functional overreaching; IL-6; IL-10; SAPK/JNK; EV; ICV; hypothalamus
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.10.027

Highlights • Excessive eccentric exercise led to central and peripheral inflammation. • The hypothalamic inflammation may be related to low body weight gain and food intake. • After a 2-week total recovery period, mice reversed central inflammation. • This recovery period normalized metabolic parameters and increased IL-10 levels.