Effect on mood of subthalamic DBS for Parkinson's disease: A consecutive series of 24 patients

• Published in: Neurology Vol. 59; no. 9; pp. 1427 - 1429
• Main Authors: BERNEY, A, VINGERHOETS, F, PERRIN, A, GUEX, P, VILLEMURE, J.-G, BURKHARD, P. R, BENKELFAT, C, GHIKA, J
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 12-11-2002
• Subjects: Adult; Affect; Aged; Biological and medical sciences; Cognition; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Depression - etiology; Electric Stimulation Therapy - adverse effects; Female; Humans; Male; Medical sciences; Middle Aged; Neurology; Parkinson Disease - psychology; Parkinson Disease - therapy; Prospective Studies; Psychomotor Performance; Subthalamic Nucleus - physiology; Human; Postoperative; Mood disorder; Nervous system diseases; Instrumentation therapy; Parkinson disease; Cognition; Cerebral disorder; Instrumental stimulation; Central nervous system disease; Evolution; Degenerative disease; Subthalamic nucleus; Extrapyramidal syndrome
• ISSN: 0028-3878; 1526-632X
• DOI: 10.1212/01.wnl.0000032756.14298.18

A series of 24 consecutive PD patients were prospectively studied prior to and within 6 months postoperatively for mood, motor, and cognitive status to investigate the effects on mood of subthalamic deep brain stimulation (DBS) in PD. In six patients (25%), mood state worsened significantly, and three were transiently suicidal despite clear motor improvement. Caregivers and patients should be educated about the potential impact of this neurosurgical procedure on mood.