Activity-dependent regulation of calcium and ribosomes in the chick cochlear nucleus

• Published in: Neuroscience Vol. 316; pp. 201 - 208
• Main Authors: Call, C.L, Hyson, R.L
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01-03-2016
• Subjects: Amino Acids - pharmacology; Analysis of Variance; Animals; auditory system; Calcium - metabolism; cell death; Chick Embryo; Cochlear Nucleus - drug effects; Cochlear Nucleus - metabolism; deafness; Electric Stimulation; Evoked Potentials, Auditory - physiology; Excitatory Amino Acid Antagonists - pharmacology; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; In Vitro Techniques; Indans - pharmacology; metabotropic glutamate receptors; Neurology; Optical Imaging; Ribosomes - metabolism; Time Factors; Xanthenes - pharmacology; eEF-2; 1-Aminoindan-1,5-dicarboxylic acid; normal goat serum; metabotropic glutamate receptors; phosphate-buffered saline; extracellular signal-regulated kinase 2; eukaryotic elongation factor-2; ERK-2; analysis of variance; ANOVA; nucleus magnocellularis; fragile X mental retardation protein; deafness; PBS; Y10B immunoreactivity; auditory system; cell death; FMRP; Y10B-ir; MCPG; artificial cerebrospinal fluid; aCSF; α-Methyl-4-carboxyphenylglycine; AIDA; NGS; mGluRs; NM
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.12.042

Highlights • [Ca2+ ]i and ribosomes (Y10B-ir) show rapid changes in NM following deafferentation. • There is a dissociation between how [Ca2+ ]i and ribosomes are regulated. • Selective mGluR receptor blockade during stimulation dissociates the two events. • Blockade of group I mGluRs affects changes in both [Ca2+ ]i and ribosomes. • Blockade of group II mGluRs affects only ribosomal changes.