Transforming growth factor-beta in the red nucleus plays antinociceptive effect under physiological and pathological pain conditions

• Published in: Neuroscience Vol. 291; pp. 37 - 45
• Main Authors: Wang, J, Yu, J, Ding, C.-P, Han, S.-P, Zeng, X.-Y, Wang, J.-Y
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 16-04-2015
• Subjects: Analgesics - administration & dosage; Animals; Antibodies - administration & dosage; Astrocytes - metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia - drug therapy; Hyperalgesia - metabolism; Male; Microglia - metabolism; Microinjections; Neuralgia - drug therapy; Neuralgia - metabolism; Neurology; Neurons - metabolism; neuropathic pain; Oligodendroglia - metabolism; Pain Threshold - drug effects; Peripheral Nerve Injuries - drug therapy; Peripheral Nerve Injuries - metabolism; Protein-Serine-Threonine Kinases - immunology; Protein-Serine-Threonine Kinases - metabolism; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta - immunology; Receptors, Transforming Growth Factor beta - metabolism; Recombinant Proteins - administration & dosage; red nucleus; Red Nucleus - drug effects; Red Nucleus - metabolism; Sciatic Nerve - injuries; spared nerve injury; Transforming Growth Factor beta - administration & dosage; Transforming Growth Factor beta - metabolism; transforming growth factor-beta; immunoreactivity; Interleukin; transforming growth factor-beta type 1 receptor; IgG; paw withdrawal threshold; SNI; transforming growth factor-beta; tumor necrosis factor-alpha; analysis of variance; ANOVA; TGF-β; immunoglobulin G; IL; MOD; CCI; red nucleus; chronic constriction injury; IR; JOR; PWT; jaw-opening reflex; TGF-β-R1; neuropathic pain; TNF-α; mean optical density; RN; spared nerve injury
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.01.059

Highlights • TGF-β and TGF-β-R1 are abundantly expressed in the red nucleus (RN) of normal rats. • The RN neurons and glia cells contribute to the expressions of TGF-β and TGF-β-R1. • TGF-β and TGF-β-R1 in the RN are down-regulated after spared nerve injury (SNI). • TGF-β in the RN plays an antinociceptive effect under physiological condition. • TGF-β in the RN plays an antinociceptive effect in neuropathic pain induced by SNI.