Preparation of a novel chitosan-g-poly(acrylamide)/Zn nanocomposite hydrogel and its applications for controlled drug delivery of ofloxacin

• Published in: International journal of biological macromolecules Vol. 84; pp. 340 - 348
• Main Authors: Pathania, Deepak, Gupta, Divya, Kothiyal, N.C., sharma, Gaurav, Eldesoky, G.E., Naushad, Mu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-03-2016
• Subjects: Acrylamide; Acrylic Resins - chemistry; Anti-Bacterial Agents - administration & dosage; Antibacterial; Chitosan; Chitosan - chemistry; Drug Carriers - chemistry; Drug delivery; Drug Delivery Systems; Drug Liberation; Escherichia coli; Microbial Sensitivity Tests; Models, Theoretical; Nanocomposite; Nanocomposites - chemistry; Nanocomposites - ultrastructure; Ofloxacin; Ofloxacin - administration & dosage; Ofloxacin - chemistry; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction; Zinc - chemistry; Acrylamide; Nanocomposite; Drug delivery; Chitosan; Antibacterial; Ofloxacin
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2015.12.041

•Chitosan-g-poly(acrylamide)/Zn (CPA-Zn) was synthesized in microwave reactor.•Different characterization techniques confirmed the formation of nanocomposite.•Drug release behavior of CPA-Zn nanocomposites were studied at different parameters.•CPA-Zn nanocomposite was investigated for an excellent antibacterial activity.
Chitosan-g-poly(acrylamide)/Zn (CPA-Zn) nanocomposite was synthesized using simple method in the presence of microwave radiations. CPA-Zn nanocomposite was characterized by various analytical techniques. CPA-Zn nanocomposite was used for controlled drug delivery of ofloxacin. The maximum drug release was 75% which was observed in acidic medium. The cumulative drug release and drug released kinetics of CPA-Zn was investigated. It was noticed that the drug release behavior depended upon the pH of medium as well as on the the nature of matrix. CPA-Zn nanocomposites were also studied for their antibacterial activity against E. coli bacteria.