Treatment of Men with Erectile Dysfunction with Transurethral Alprostadil

• Published in: The New England journal of medicine Vol. 336; no. 1; pp. 1 - 7
• Main Authors: Padma-Nathan, Harin, Hellstrom, Wayne J.G, Kaiser, Fran E, Labasky, Richard F, Lue, Tom F, Nolten, Wolfram E, Norwood, Paul C, Peterson, Craig A, Shabsigh, Ridwan, Tam, Peter Y, Place, Virgil A, Gesundheit, Neil, Cowley, Christy, Nemo, Kerry J, Spivack, Alfred P, Stephens, Darby E, Todd, Leslie K
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 02-01-1997
• Subjects: Biological and medical sciences; Diabetes; Drug dosages; Family medical history; Genital system. Reproduction; Medical sciences; Men; Pharmacology. Drug treatments; Sexual disorders; Surgery; Human; Prospective; Chemotherapy; Treatment; Erection disorders; Prostaglandin E1; Clinical trial; Male genital diseases; Alprostadil
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199701023360101

Erectile dysfunction (impotence) affects approximately 10 million to 20 million men in the United States.
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,
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It becomes more frequent with age,
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but is not an inevitable consequence of normal aging.
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It is usually due to organic factors or diseases, such as pelvic vascular disease, diabetes mellitus, neurodegenerative disorders, side effects of medication, pelvic surgery, and trauma.
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,
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Erectile dysfunction impairs sexual performance, diminishes self-esteem,
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,
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and disrupts personal relationships.
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Current treatments for erectile dysfunction include oral medications, vacuum pumps, vascular surgery, penile prostheses, and intracavernosal injections. Oral medications, such as yohimbine, have limited efficacy.
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,
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Vacuum pumps may be . . .