Association of insulin receptor H1085H C>T, insulin receptor substrate 1 G972R and insulin receptor substrate 2 1057G/A polymorphisms with refractory temporal lobe epilepsy in Han Chinese

• Published in: Seizure (London, England) Vol. 25; pp. 178 - 180
• Main Authors: Che, Fengyuan, Fu, Qingxi, Li, Xuesong, Gao, Naiyong, Qi, Faying, Sun, Zhiqing, Du, Yifeng, Li, Ming
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-02-2015
• Subjects: Adult; Alleles; Anticonvulsants - therapeutic use; Antigens, CD - genetics; Asian Continental Ancestry Group - genetics; Case-Control Studies; China; Drug resistance; Drug Resistance - genetics; Epilepsy, temporal lobe; Epilepsy, Temporal Lobe - drug therapy; Epilepsy, Temporal Lobe - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Insulin receptor substrate proteins; Insulin Receptor Substrate Proteins - genetics; Male; Neurology; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptor, Insulin - genetics; China; Insulin receptor substrate proteins; Epilepsy, temporal lobe; Polymorphism, single nucleotide; Drug resistance
• ISSN: 1059-1311; 1532-2688
• DOI: 10.1016/j.seizure.2014.09.014

Highlights • Association between insulin signaling gene polymorphism and refractory TLE was studied. • INSR H1085H C>T, IRS1 G972R and IRS2 1057G/A were genotyped. • INSR H1085H “T” allele may be a genetic risk factor for drug resistance in TLE. • IRS2 “A” allele combined with INSR “T” allele increased the risk of drug resistance.