Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency

• Published in: Taiwanese journal of obstetrics & gynecology Vol. 58; no. 6; pp. 849 - 851
• Main Authors: Fujibe, Yuya, Mariya, Tasuku, Mizuuchi, Masahito, Ishioka, Shinichi, Yoshida, Masahiro, Saito, Tsuyoshi
• Format: Journal Article
• Language: English
• Published: China (Republic : 1949- ) Elsevier B.V 01-11-2019; Elsevier
• Subjects: Adult; Antithrombin III - administration & dosage; Antithrombin III Deficiency - complications; Antithrombin III Deficiency - drug therapy; Antithrombins - administration & dosage; Female; Hereditary antithrombin deficiency; Humans; Infant, Newborn; Injections, Intravenous; Japan; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Outcome; Prophylaxis; Recombinant human antithrombin; Recombinant Proteins; Venous thromboembolism; Venous Thromboembolism - etiology; Venous Thromboembolism - prevention & control; Japan; Pregnancy; Recombinant human antithrombin; Venous thromboembolism; Prophylaxis; Hereditary antithrombin deficiency
• ISSN: 1028-4559; 1875-6263
• DOI: 10.1016/j.tjog.2019.09.021

Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency.
A 30-year-old woman, gravida 2 para 0, was referred to our hospital because of AT deficiency. Unfractionated heparin was administered from 13 weeks of gestation and rhAT was administered from labor onset. A cesarean section was performed and the patient and her baby were healthy, with no sequelae.
We concluded that rhAT was effective for preventing VTE during delivery, with no potential infection risks.