Lack of association between early childhood immunizations and beta-cell autoimmunity

• Published in: Diabetes care Vol. 22; no. 10; pp. 1694 - 1697
• Main Authors: GRAVES, P. M, BARRIGA, K. J, NORRIS, J. M, HOFFMAN, M. R, LIPING YU, EISENBARTH, G. S, REWERS, M
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01-10-1999
• Subjects: Age; Autoantibodies - blood; Biological and medical sciences; Case-Control Studies; Child; Child, Preschool; Children; Diabetes; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diabetes. Impaired glucose tolerance; Diphtheria; Diphtheria-Tetanus-Pertussis Vaccine - immunology; Disease; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Family; Female; Glutamate Decarboxylase - immunology; Haemophilus influenzae type b - immunology; Haemophilus Vaccines - immunology; Health aspects; Hepatitis B; Hepatitis B Vaccines - immunology; Humans; Hypotheses; Immunization - adverse effects; Infant; Insulin; Insulin Antibodies - blood; Islets of Langerhans - immunology; Male; Medical research; Medical sciences; Meningitis; Poliomyelitis; Poliovirus Vaccine, Inactivated - immunology; Reference Values; Research design; Risk factors; Tetanus; Type 1 diabetes; Vaccination; Vaccination of children; Vaccines; Whooping cough; United States; North America; America; United States > US; Colorado; Endocrinopathy; Human; Immunopathology; Vaccination; Autoantibody; Autoimmune disease; Infant; Sibling; Insulin; Blood plasma; Islet Cell antibody; Immunological investigation; Insulin dependent diabetes; Child; Comparative study
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.22.10.1694

Lack of association between early childhood immunizations and beta-cell autoimmunity.
P M Graves ,
K J Barriga ,
J M Norris ,
M R Hoffman ,
L Yu ,
G S Eisenbarth and
M Rewers
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA. [e-mail]
Abstract
OBJECTIVE: To determine whether early childhood immunization history affects the risk of developing the beta-cell autoimmunity
that precedes type 1 diabetes. RESEARCH DESIGN AND METHODS: This article describes a case-control study whose participants
were 317 children aged < or = 12 years who have a first-degree relative with type 1 diabetes. The children were enrolled in
a prospective cohort study of the etiology of beta-cell autoimmunity, the Diabetes Autoimmunity Study in the Young, in Denver,
Colorado. The main outcome measure was beta-cell autoimmunity as determined by persistent autoantibodies against insulin,
GAD, or islet cell antibody (IA-2) 512. The number of cases with beta-cell autoimmunity was 25, and the number of control
subjects (the remainder of the cohort) was 292. RESULTS: There was no difference between cases and control subjects in the
proportion receiving hepatitis B (HBV), Haemophilus influenzae b (Hib), polio, or diphtheria tetanus pertussis (DTP) vaccines
before 9 months of age; in the proportion receiving HBV at birth rather than later; or in the median age at first HBV, Hib,
polio, or DTP vaccination. CONCLUSIONS: The results suggest that changing the early childhood immunization schedule would
not affect the risk of developing beta-cell autoimmunity or type 1 diabetes.