Prospective demonstration of short-term motor plasticity following acquired central pareses

• Published in: NeuroImage (Orlando, Fla.) Vol. 24; no. 4; pp. 1248 - 1255
• Main Authors: Reinges, Marcus H.T., Krings, Timo, Rohde, Veit, Hans, Franz-Josef, Willmes, Klaus, Thron, Armin, Gilsbach, Joachim M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15-02-2005; Elsevier Limited
• Subjects: Adult; Age; Aged; Algorithms; Brain cancer; Brain Neoplasms - surgery; Brain tumor; Female; Functional magnetic resonance imaging; Humans; Hypotheses; Magnetic Resonance Imaging; Male; Middle Aged; Motor cortex; Motor Neurons - physiology; Muscle, Skeletal - innervation; Muscle, Skeletal - physiopathology; Neuronal Plasticity - physiology; Neurosurgical Procedures; Paresis - physiopathology; Postoperative Complications - physiopathology; Prospective Studies; Psychomotor Performance; Short-term plasticity; Surgery; Tumors; Brain tumor; Short-term plasticity; Functional magnetic resonance imaging; Motor cortex
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2004.11.002

The effect of newly acquired central pareses on functional MRI (fMRI) signal pattern is not known, since up to now all investigated patients were examined while they already experienced the motor weakness. We describe the first prospective and controlled study demonstrating the impact of new, acquired central pareses on fMRI motor activation pattern. Six patients suffering from a new central paresis after resection of a brain tumor infiltrating the central region were prospectively compared with a control group of five patients without postoperative paresis and a group of six healthy, age-matched controls who were investigated at two time points. fMRI signal was postoperatively analyzed during the performance of hand motor tasks and compared to the preoperative fMRI results. The relative signal change between rest and activation was evaluated for five cortical regions: the primary motor cortex (M1) and the ipsilateral primary motor cortex (M1i), the supplementary motor area (SMA), the premotor area (PMA), and the superior parietal lobule (SPL). In the patients with new postoperative central pareses, significant (
P = 0.0313) decreases in fMRI activation were found in M1, whereas significant (
P = 0.0313) increases were found in SMA and PMA. For M1i and SPL, there was a signal increase on average as well, but it failed to reach significance (
P = 0.1250). In both control groups, no significant changes between both examinations were seen. Even though the number of investigated patients is too small to draw definite conclusions, our results support the concept of short-term motor plasticity being mediated by redundant systems that may take over function after damage of the primary motor cortex. The findings potentially also reflect increased functional demands imposed upon the motor network subsequent to a loss of dexterity.