Immunodeficiency-associated viral oncogenesis

Immunodeficiency-associated viral oncogenesis

Several viruses with different replication mechanisms contribute to oncogenesis by both direct and indirect mechanisms in immunosuppressed subjects after solid organ transplantation, after allogeneic stem cell transplantation, or with human immunodeficiency virus (HIV) infection. Epstein–Barr virus...

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Bibliographic Details
Published in:Clinical microbiology and infection Vol. 21; no. 11; pp. 975 - 983
Main Authors: Pierangeli, A., Antonelli, G., Gentile, G.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-11-2015
Subjects:
Carcinogenesis
HIV
Humans
Immunocompromised Host
immunodeficiency
Neoplasms - epidemiology
Neoplasms - pathology
Oncogenic Viruses - growth & development
transplantation
viral oncogenesis
Virus Diseases - complications
Virus Diseases - virology
viral oncogenesis
immunodeficiency
HIV
Carcinogenesis
transplantation
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Summary:Several viruses with different replication mechanisms contribute to oncogenesis by both direct and indirect mechanisms in immunosuppressed subjects after solid organ transplantation, after allogeneic stem cell transplantation, or with human immunodeficiency virus (HIV) infection. Epstein–Barr virus (EBV), human papillomavirus (HPV), Kaposi sarcoma herpesvirus (KSHV), human T-cell lymphotropic virus type 1 (HTLV-1) and Merkel cell polyoma virus (MCV) are the main viruses associated with the development of cancer in immunosuppressed patients. Besides being a main cause of immunodeficiency, HIV1 has a direct pro-oncogenic effect. In this review, we provide an update on the association between the condition of acquired immunodeficiency and cancer risk, specifically addressing the contributions to oncogenesis of HPV, MCV, KSHV, HTLV-1, and EBV.
ISSN:1198-743X
1469-0691
DOI:10.1016/j.cmi.2015.07.009