Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar

• Published in: Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 98; no. 5; pp. 311 - 314
• Main Authors: Willcox, M.L, Rakotondrazafy, E, Andriamanalimanana, R, Andrianasolo, D, Rasoanaivo, P
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01-05-2004; Royal Society of Tropical Medicine and Hygiene; Elsevier
• Subjects: Adolescent; Adult; Antimalarials - therapeutic use; Biological and medical sciences; Child; Child, Preschool; Chloroquine; Chloroquine - therapeutic use; Clinical efficacy; Drug Resistance; Female; Follow-Up Studies; Human protozoal diseases; Humans; Infectious diseases; Madagascar; Madagascar Highlands; Malaria; Malaria - drug therapy; Male; Medical sciences; Middle Aged; Parasitic diseases; Protozoal diseases; Treatment Failure; Malagasy Republic; Africa; Madagascar; Madagascar Highlands; Malaria; Drug resistance; Chloroquine; Clinical efficacy; Human; Antimalarial; Protozoal disease; Treatment resistance; Parasitosis; Infection; Parasiticide; Tropical medicine; Antirheumatic agent
• ISSN: 0035-9203; 1878-3503
• DOI: 10.1016/j.trstmh.2003.10.002

The clinical efficacy of chloroquine was assessed in the Primary Health Centre of Ankazobe, Central Highlands of Madagascar. This study shows an increase in the level of chloroquine resistance with the appearance of early treatment failures and RIII resistance. Furthermore, the prevalence of clinical treatment failures is approaching the level of 25%, at which WHO recommends a change of first-line drug.