The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats

• Published in: World journal of urology Vol. 29; no. 1; pp. 127 - 132
• Main Authors: Silici, Sibel, Ekmekcioglu, Oguz, Kanbur, Murat, Deniz, Kemal
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01-02-2011; Springer; Springer Nature B.V
• Subjects: Animals; Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacology; Antioxidants - therapeutic use; Biological and medical sciences; Blood Urea Nitrogen; Catalase - metabolism; Cisplatin - adverse effects; Cisplatin - pharmacology; Fatty Acids - therapeutic use; Glutathione Peroxidase - metabolism; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Male; Malondialdehyde - metabolism; Medical sciences; Medicine; Medicine & Public Health; Models, Animal; Nephrology; Nephrology. Urinary tract diseases; Oncology; Original Article; Oxidative Stress - drug effects; Rats; Rats, Wistar; Renal Insufficiency - chemically induced; Renal Insufficiency - metabolism; Renal Insufficiency - prevention & control; Superoxide Dismutase - metabolism; Urology; Royal jelly; Antioxidants; Nephrotoxicity; Cisplatin; Antineoplastic agent; Oxidative stress; Nephrology; Rat; Toxicity; Rodentia; Protective factor; Antioxidant; Kidney; Urology; Alkylating agent; Vertebrata; Mammalia; Urinary system; Animal; Platinum II Complexes
• ISSN: 0724-4983; 1433-8726
• DOI: 10.1007/s00345-010-0543-5

Background
The aim of this study was to investigate the effects of royal jelly on cisplatin-induced nephrotoxicity and oxidative stress in rats.
Methods
Adult male Wistar albino rats were randomly divided into eight groups: the control, cisplatin, royal jelly, and royal jelly plus cisplatin groups. Biochemical and histopathological methods were utilized for evaluation of the nephrotoxicity. Blood was collected and analyzed for blood urea nitrogen (BUN), alanine aminotransferase, aspartate aminotransferase, triglyceride, total cholesterol, uric acid, total bilirubin, and total protein levels. The kidney samples were stored for the measurement of malondialdehyde (MDA), glutathione peroxidase (GSHPx), superoxide dismutase (SOD), and catalase (CAT) activities and processed for histopathological examinations.
Results
Administration of cisplatin to rats induced a marked renal failure, characterized with a significant increase in serum BUN and uric acid concentrations, and they had higher kidney MDA and lower GSH-Px, SOD, and CAT activities. In the groups that were administered RJ in association with CP, improvement was observed in some oxidative stress parameters and certain other biochemical parameters, pre-treatment with RJ being more effective.
Conclusions
The CP-induced changes in histopathologic findings of kidneys were partially reversed by treatment with royal jelly. The results provide further insight into the mechanisms of CP-induced nephrotoxicity and confirm the antioxidant potential of royal jelly.