Effect of Resistance, Endurance, and Concurrent Training on TNF-α, IL-6, and CRP

• Published in: Medicine and science in sports and exercise Vol. 44; no. 1; pp. 50 - 56
• Main Authors: LIBARDI, Cleiton Augusto, DE SOUZA, Giovana Verginia, CAVAGLIERI, Claudia Regina, MADRUGA, Vera Aparecida, TRAINA CHACON-MIKAHIL, Mara Patricia
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 2012
• Subjects: Adult; Biological and medical sciences; C-Reactive Protein - analysis; C-Reactive Protein - physiology; Fundamental and applied biological sciences. Psychology; Humans; Interleukin-6 - blood; Lipids - blood; Male; Middle Aged; Muscle Strength - physiology; Muscle, Skeletal - physiology; Oxygen Consumption - physiology; Physical Endurance - physiology; Resistance Training; Sedentary Lifestyle; Space life sciences; Tumor Necrosis Factor-alpha - blood; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; Weight Lifting - physiology; Human; Interleukin 6; Sport; Physical training; Cytokine; AEROBIC TRAINING; COMBINED TRAINING; Endurance; Inflammation; Tumor necrosis factor α; INFLAMMATORY MARKERS; STRENGTH TRAINING
• ISSN: 0195-9131; 1530-0315
• DOI: 10.1249/MSS.0b013e318229d2e9

The aim of the present study was to evaluate the effects of 16 wk of resistance training (RT), endurance training (ET), and concurrent training (CT) on inflammatory markers, C-reactive protein (CRP), and functional capacity in sedentary middle-age men.
Healthy subjects were randomized into RT (n = 11), ET (n = 12), CT (n = 11), and a control group (n = 13). The subjects performed three weekly sessions lasting about 60 min for 16 wk. Maximal strength was tested in bench press and leg press. The peak oxygen uptake (VO2peak) was measured in an incremental exercise test. Plasma tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and CRP levels were determined by an enzyme-linked immunosorbent assay.
Maximal strength was increased after 16 wk, with no differences between RT and CT. VO2peak increased in ET and CT comparing before and after training. There were no significant differences in TNF-α, IL-6, and CRP comparing before and after training.
Sixteen weeks of RT, ET, or CT in middle-age healthy men has not affected low and moderate IL-6, TNF-α, and CRP levels. CT performed in the same weekly frequency and session duration of ET and RT was effective in increasing both maximal strength and VO2peak, in addition to improvements in lipid profile.