Epstein-Barr virus and gastric cancer: data and unanswered questions

Sixty-five unselected cases of gastric cancer have been analysed for EBV DNA by polymerase chain reaction, in situ hybridization and immunohistochemistry for CD21 antigen expression. Four cases were found EBV-positive by PCR, while ISH yielded positive results in 3 of these cases, demonstrating EBV...

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Bibliographic Details
Published in:	International journal of cancer Vol. 53; no. 6; p. 898
Main Authors:	Leoncini, L, Vindigni, C, Megha, T, Funtò, I, Pacenti, L, Musarò, M, Renieri, A, Seri, M, Anagnostopoulos, J, Tosi, P
Format:	Journal Article
Language:	English
Published:	United States 01-04-1993
Subjects:	Adenocarcinoma - microbiology Adult Aged Aged, 80 and over Base Sequence Dendritic Cells - chemistry DNA, Viral - analysis Female Herpesvirus 4, Human - genetics Humans Immunohistochemistry In Situ Hybridization Lymphoid Tissue - chemistry Male Microtomy Middle Aged Molecular Sequence Data Neoplasm Staging Paraffin Embedding Polymerase Chain Reaction Receptors, Complement 3d Staining and Labeling - methods Stomach Neoplasms - microbiology
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Summary:	Sixty-five unselected cases of gastric cancer have been analysed for EBV DNA by polymerase chain reaction, in situ hybridization and immunohistochemistry for CD21 antigen expression. Four cases were found EBV-positive by PCR, while ISH yielded positive results in 3 of these cases, demonstrating EBV in the nuclei of cancerous cells. CD21 antigen was expressed in cancerous cells in all 3 ISH-positive cases. All the EBV-positive cancers of the present series were poorly to moderately differentiated adenocarcinomas with prominent lymphoid infiltration. These results are discussed also on the basis of the literature.
ISSN:	0020-7136
DOI:	10.1002/ijc.2910530605