Different linkage disequilibria of HLA-B27 subtypes and HLA-C locus alleles

Subtypes of HLA-B27 have been identified by cellular, serological and biochemical techniques. Comparison of the various B27 subtype designations showed the existence of seven B27 subtypes. The new WHO nomenclature (1987) of the B27 subtypes is included. We further report on different linkage disequi...

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Bibliographic Details
Published in:	Tissue antigens Vol. 32; no. 2; p. 74
Main Authors:	Breur-Vriesendorp, B S, de Waal, L P, Ivanyi, P
Format:	Journal Article
Language:	English
Published:	England 01-08-1988
Subjects:	Alleles Genetic Linkage HLA-B Antigens - genetics HLA-B Antigens - immunology HLA-B27 Antigen HLA-C Antigens - genetics HLA-C Antigens - immunology Humans
Online Access:	Get more information
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Summary:	Subtypes of HLA-B27 have been identified by cellular, serological and biochemical techniques. Comparison of the various B27 subtype designations showed the existence of seven B27 subtypes. The new WHO nomenclature (1987) of the B27 subtypes is included. We further report on different linkage disequilibria (ld) of the B27 subtypes. In Caucasoids, the prevalent subtype B27.5 is in ld with Cw1 and Cw2, whereas B27.2 is linked only with Cw2. In Orientals, the most frequent subtypes B27.4 and B27.6 usually occur with Cw3 or Cw blank; B27.5 mostly occurs with Cw2, and B27.2 is almost absent.
ISSN:	0001-2815
DOI:	10.1111/j.1399-0039.1988.tb01640.x