Reference values for peripheral blood lymphocytes from Aotus lemurinus ssp. griseimembra (owl monkey)

The reactivities of several monoclonal antibodies that define human lymphocyte cell-surface antigens have been tested with peripheral blood lymphocytes of Aotus lemurinus ssp. griseimembra. Based on reactivity patterns in humans, reactive MoAb were identified that mark pan-T, helper/inducer, suppres...

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Bibliographic Details
Published in:	Journal of medical primatology Vol. 16; no. 4; p. 261
Main Authors:	Caldwell, C W, Mrema, J E, Taylor, H M, Green, T J
Format:	Journal Article
Language:	English
Published:	Denmark 01-01-1987
Subjects:	Animals Antibodies, Monoclonal Aotus trivirgatus - blood Aotus trivirgatus - immunology B-Lymphocytes - immunology Cebidae - immunology Flow Cytometry Fluorescent Antibody Technique Killer Cells, Natural - immunology Leukocyte Count - veterinary Lymphocytes - classification Lymphocytes - immunology Reference Values T-Lymphocytes - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory - immunology
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Summary:	The reactivities of several monoclonal antibodies that define human lymphocyte cell-surface antigens have been tested with peripheral blood lymphocytes of Aotus lemurinus ssp. griseimembra. Based on reactivity patterns in humans, reactive MoAb were identified that mark pan-T, helper/inducer, suppressor/cytotoxic, pan-B, and natural killer cells. Reference values of these subsets in Aotus are presented. These MoAb should provide a useful tool for further phenotypic and functional dissection of the immune system in this simian model of human disease.
ISSN:	0047-2565
DOI:	10.1111/j.1600-0684.1987.tb00334.x