Subtherapeutic Ocular Penetration of Caspofungin and Associated Treatment Failure in Candida albicans Endophthalmitis

Candida endophthalmitis represents the most serious ocular complication of candidemia. The pharmacokinetics and pharmacodynamics of fluconazole, amphotericin B, and flucytosine are fairly well established in endophthalmitis therapy. There remains a paucity of clinical data regarding the utility of n...

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Bibliographic Details
Published in:	Clinical infectious diseases Vol. 41; no. 3; pp. e27 - e28
Main Authors:	Gauthier, G. M., Nork, T. M., Prince, R., Andes, D.
Format:	Journal Article
Language:	English
Published:	United States The University of Chicago Press 01-08-2005 Oxford University Press
Subjects:	Adult Amphotericin B - therapeutic use Antifungal Agents - therapeutic use Candida albicans Candidiasis - drug therapy Drug Combinations Echinocandins Endophthalmitis - drug therapy Humans Lipopeptides Male Peptides, Cyclic - therapeutic use Phosphatidylcholines - therapeutic use Phosphatidylglycerols - therapeutic use Treatment Failure
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Summary:	Candida endophthalmitis represents the most serious ocular complication of candidemia. The pharmacokinetics and pharmacodynamics of fluconazole, amphotericin B, and flucytosine are fairly well established in endophthalmitis therapy. There remains a paucity of clinical data regarding the utility of new antimycotic agents in the treatment of fungal chorioretinitis and endophthalmitis. We report a case of clinical failure of caspofungin in the management of Candida albicans endophthalmitis associated with poor vitreous penetration.
Bibliography:	ark:/67375/HXZ-8QXSNRRM-M istex:85C8519A1185798956AA7C80667C16DBEF1AE63B ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1058-4838 1537-6591
DOI:	10.1086/431761