Established and Emerging Treatments of Skin GvHD

• Published in: Frontiers in immunology Vol. 13; p. 838494
• Main Authors: Link-Rachner, Cornelia S, Sockel, Katja, Schuetz, Catharina
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02-02-2022
• Subjects: Acute Disease; acute skin GvHD; cell-based therapy; Chronic Disease; chronic skin GvHD; cutaneous GvHD; Graft vs Host Disease - etiology; Graft vs Host Disease - therapy; Graft-versus-host disease; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Immunology; Organ Specificity; Randomized Controlled Trials as Topic; Skin Diseases - etiology; Skin Diseases - therapy; targeted therapy; Transplantation, Homologous - adverse effects; Graft-versus-host disease; targeted therapy; GvHD therapies; cell-based therapy; GvHD treatment; acute skin GvHD; chronic skin GvHD; cutaneous GvHD
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2022.838494

Graft-versus-host disease (GvHD) of the skin is a severe allo-immune reaction and complication following allogeneic stem cell transplantation. Over the past years, intensive pre-clinical research has led to an improved understanding of the pathophysiology of acute and to a lesser extend chronic GvHD. This has translated into the approval of several new agents for the treatment of both forms of GvHD. This review summarizes the most recent advances in underlying pathomechanisms, clinical trials and newly approved agents for GvHD, with a special focus on skin involvement.