Effects of Paternal Obesity on Fetal Development and Pregnancy Complications: A Prospective Clinical Cohort Study

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 826665
• Main Authors: Lin, Jing, Gu, Wei, Huang, Hefeng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14-03-2022
• Subjects: Cesarean Section; Cohort Studies; cohort study; Endocrinology; Female; Fetal Development; Humans; Infant, Newborn; macrosomia; Obesity - complications; Obesity - epidemiology; paternal obesity; Placenta; preeclampsia; Pregnancy; Pregnancy Outcome - epidemiology; Prospective Studies; SGA; cohort study; preeclampsia; SGA; macrosomia; paternal obesity
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2022.826665

To evaluate the association between paternal obesity and fetal development and pregnancy complications.
This prospective cohort clinical trial analyzed data from 7683 women with singleton pregnancies. All study subjects were sequentially divided into four groups based on paternal BMI. We compared the differences in fetal growth and pregnancy complications between different paternal BMI groups by univariate logistic regression and independent t-test. Finally, the independent predictors of SGA and macrosomia were determined.
The incidences of preeclampsia, cesarean section, SGA, macrosomia, and postpartum hemorrhage in the paternal obesity group were significantly higher than the normal BMI group. With the increase of paternal BMI, fetal ultrasound measurement parameter, neonatal and placental weight showed an increasing trend (trend P < 0.05). However, these differences disappeared in the obese group. The test for interaction showed the effect of paternal obesity on SGA and macrosomia was significantly affected by maternal obesity. We also found paternal obesity was an independent predictor of both SGA and macrosomia. Based on the above results, we plotted the Nomograms for clinical prediction.
Paternal obesity can affect fetal growth parameters and placental development, which has an adverse impact on pregnancy outcomes. Optimizing the paternal BMI will help improve the health of the next generation.