Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer

• Published in: British journal of cancer Vol. 89; no. 6; pp. 1028 - 1030
• Main Authors: FORREST, L. M, MCMILLAN, D. C, MCARDLE, C. S, ANGERSON, W. J, DUNLOP, D. J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 15-09-2003
• Subjects: Adenocarcinoma - blood; Adenocarcinoma - diagnosis; Albumins - analysis; Biological and medical sciences; Biomarkers, Tumor - analysis; C-Reactive Protein - analysis; Carcinoma, Non-Small-Cell Lung - blood; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - diagnosis; Female; Humans; Hypoalbuminemia - complications; Inflammation; Karnofsky Performance Status; Lung cancer; Lung Neoplasms - blood; Lung Neoplasms - diagnosis; Male; Medical sciences; Middle Aged; Molecular and Cellular Pathology; Neoplasm Staging; Pneumology; Prognosis; Prospective Studies; Retrospective Studies; Tumors of the respiratory system and mediastinum; Human; non-small-cell lung cancer cumulative prognostic score; Lung disease; Prognosis; C-reactive protein; Physical performance; Respiratory disease; Inflammation; Systemic; Malignant tumor; non-small cell lung carcinoma; stage; albumin; Unresectable; Bronchus disease; performance status; C reactive protein
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6601242

A score based on the combination of the systemic inflammatory response and albumin hazards ratio (HR) 1.70, 95% CI 1.23 - 2.35, P=0.001) was comparable in prognostic value to that based on stage and performance status (HR 1.48, 95% CI 1.12 - 1.95, P=0.006) in patients with inoperable non-small-cell lung cancer. The former is simple to measure and well standardised.